In vitro antioxidant activity and carbonic anhydrase inhibitory features of Ferula communis extracts

Carbonic anhydrases (CAs; EC 4.2.1.1) are essential family of metalloenzymes which catalyze the interconversion between carbon dioxide (CO2) and bicarbonate (HCO3-) in all organisms three-domains life. Huge amounts attempts related to catalytic activity CAs have been widely expanded treat many clinical diseases. This study aimed determine in-vitro antioxidant activities human CA I (hCA I) II II) inhibitory properties Ferula communis extracts. Among extracts F. communis, hexane extract has showed best profile on hCA with IC50 values 8.68 µg/mL 28 Ki 2.026 11.6 µg/mL, respectively. All mild moderate activity. According results DPPH assay, ethanol-water highest IC50: 0.1128±0.0066 value. Chloroform CUPRAC assay value 1.305±0.037 mM Trolox equivalent/mg extract. However, further analytical, in-vivo studies needed confirm communis.